Neuropathic orofacial pain: Facts and fiction

Neuropathic orofacial pain.

Neuropathic orofacial pain (NOP) is a challenging diagnostic problem. In some cases, symptomatology may be similar to that seen with dental pathology, resulting in unwarranted dental treatment. Rarely, NOP can herald serious disease or central tumors, and early diagnosis can be life-saving. The following review outlines the classification, clinical presentation, pathophysiology, and treatment o...

Orofacial Neuralgias and Neuropathic Pain

One of the most challenging clinical issues the dentist confronts is the patient with persistent orofacial pain without obvious proximate physical cause. Patients with persistent pain often seek consultation from many clinicians and undergo multiple unnecessary procedures before receiving a correct diagnosis and appropriate treatment. Clinicians unfamiliar with neuropathic pain may become frust...

Orofacial neuropathic pain induced by oxaliplatin

Abstract Neuropathic pain induced by chemotherapy drugs such as oxaliplatin is a dose-limiting side effect in cancer treatment. The mechanisms underlying chemotherapy-induced neuropathic pain are not fully understood. KCNQ2 channels are low-threshold voltage-gated K+ channels that play a role in controlling neuronal excitability. Downregulation of KCNQ2 channels has been proposed to be an under...

Asbestos: facts and fiction.

Asbestos: Facts and Fiction I appreciate the opportunity to address the omissions, inaccuracies, and innuendos in the position paper by David P. Rall, "Media and Science: Harmless Dioxin, Benign CFCs, and Good Asbestos" (EHP 102:10). Unfortunately, Rail not only misinterprets the conclusions of our 1990 Science article by Mossman et al. (1) but he fails to mention the database, scientific panel...

Leprosy: Facts and Fiction